ABSTRACT
Introduction: The 2019 novel coronavirus disease (COVID-19) was first detected in December 2019 and became an epidemic in Wuhan, Hubei province, China. The immune system is known to be dysregulated during the course of this disease. Objective: Present updated information related to the immunology of pregnancy and COVID-19 infection. Methods: The information search for this review was carried out in the PubMed, EBSCO, Scopus and Scielo databases. The main search engine was Google Scholar. An analysis of the recovered articles was carried out in order to select the most rigorous and important ones. Analysis and synthesis of the information: Compared to the general population, pregnant women do not appear to be more susceptible to the consequences of COVID-19 infection. However, due to the physiological changes that take place, pregnant women are considered a vulnerable population with respect to viral respiratory infections. This virus can alter the immune response at the maternal-fetal interface and affect the well-being of the mother and child. However, it is not associated with major maternal or neonatal complications. These data should be taken with caution, since the number of pregnancy reports is still considered small to make a definitive statement. Conclusions: Although there are few reported cases, the clinical characteristics reported in pregnant women with confirmed COVID-19 infection are similar to those reported for non-pregnant adults in the general population and are indicative of a relatively optimistic clinical course based on the results. for this infection.
ABSTRACT
Introduction: Havana city was the most complex territory at the national level facingthe first outbreak of COVID-19. Its condition of capital, the population density, the limited geographical delimitation between its municipalities, the high inter-municipal and inter-provincial flow of people, added to the fact that it is the province that receives the largest number of travelers from abroad, conferred particularities on this territory. Objective: To determine the main clinical-epidemiological characteristics of patients affected by COVID-19 living in Havana. Methods: An observational, analytical, cross-sectional study was carried out. The sample contained 431 patients, older than one year, with epidemiological discharge from the SARS-CoV-2 infection. To collect information, a questionnaire was applied through an interview. Results: The average age of the sample was 45 years. More than half of the cases evolved in a symptomatic way (not serious or serious). Fever was the most frequent clinical manifestation. The individuals included in the sample, with blood group O or with a background of asthma, showed less risk of presenting symptomatic forms of the disease. Conclusions: The results suggest that age is the main risk factor for developing symptomatic forms (not severe or severe) of COVID-19. On the contrary, blood group O and a history of asthma are protective factors for these forms of clinical evolution. © 2021, Editorial Ciencias Medicas. All rights reserved.
ABSTRACT
COVID-19 has had severe consequences worldwide. It has been estimated that the contribution of genetic factors to the disease is about 50%. The A16974C polymorphism of the IL-12 p40 gene has been described as being related to resistance or susceptibility to other infectious diseases;therefore, it is likely that it can also be related to COVID-19. The objective of this study was to describe the relationship between the A16974C polymorphism of the IL12 p40 gene with clinical forms of COVID-19 in Cuban patients. The genotypes of the A16974C polymorphism of gene IL-12 p40 were determined through PCR in 102 persons with a COVID-19 epidemiologic discharge from the hospital. In this research, the CC genotype of this polymorphism was found only in symptomatic cases of this disease;since there are signs of relationship between the A16974C polymorphism of the IL12 p40 gene with clinical forms of COVID-19 in the studied Cuban patients, the variations of this polymorphism may be a predisposing risk factor in the development of COVID-19. © 2022 by the authors.
ABSTRACT
Purpose: To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods: TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results: There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243-17.842], even severe [OR = 1.200, 95% CI: 0.217-6.638], related to the tt genotype. Conclusion: There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.